1312446-92-6Relevant academic research and scientific papers
Quinazolinedione sulfonamides: A novel class of competitive AMPA receptor antagonists with oral activity
Koller, Manuel,Lingenhoehl, Kurt,Schmutz, Markus,Vranesic, Ivan-Toma,Kallen, Joerg,Auberson, Yves P.,Carcache, David A.,Mattes, Henri,Ofner, Silvio,Orain, David,Urwyler, Stephan
, p. 3358 - 3361 (2011)
Quinazoline-2,4-diones with a sulfonamide group attached to the N(3) ring atom constitute a novel class of competitive AMPA receptor antagonists. One of the synthesized compounds, 28, shows nanomolar receptor affinity, whereas other examples of the series display oral anticonvulsant activity in animal models.
