1312471-07-0Relevant academic research and scientific papers
Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides
Chandrika, Nishad Thamban,Green, Keith D.,Houghton, Jacob L.,Garneau-Tsodikova, Sylvie
supporting information, p. 1134 - 1139 (2015/11/24)
Despite issues with oto/nephrotoxicity and bacterial resistance, aminoglycosides (AGs) remain an effective and widely used class of antibacterial agents. For decades now, efforts toward the development of novel AGs with potential to overcome some of these
Assessment of 6′- and 6′′′-N-acylation of aminoglycosides as a strategy to overcome bacterial resistance
Shaul, Pazit,Green, Keith D.,Rutenberg, Roi,Kramer, Maria,Berkov-Zrihen, Yifat,Breiner-Goldstein, Elinor,Garneau-Tsodikova, Sylvie,Fridman, Micha
experimental part, p. 4057 - 4063 (2011/06/28)
Amongst the many synthetic aminoglycoside analogues that were developed to regain the efficacy of this class of antibiotics against resistant bacterial strains, the 1-N-acylated analogues are the most clinically used. In this study we demonstrate that 6′-
