1312550-16-5

Basic information

• Product Name: N-cyclohexyl-8-morpholino-2-(4-nitrophenyl)imidazo[1,2-a]pyrazin-3-amine
• Synonyms: N-cyclohexyl-8-morpholino-2-(4-nitrophenyl)imidazo[1,2-a]pyrazin-3-amine
• CAS NO: 1312550-16-5
• Molecular Weight: 422.487
• Mol File: 1312550-16-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-cyclohexyl-8-morpholino-2-(4-nitrophenyl)imidazo[1,2-a]pyrazin-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexyl-8-morpholino-2-(4-nitrophenyl)imidazo[1,2-a]pyrazin-3-amine(1312550-16-5)
• EPA Substance Registry System: N-cyclohexyl-8-morpholino-2-(4-nitrophenyl)imidazo[1,2-a]pyrazin-3-amine(1312550-16-5)

Safety Data

• Hazardous Substances Data: 1312550-16-5(Hazardous Substances Data)

Upstream product

• 931-53-3 Cyclohexyl isocyanide 
• 117719-16-1 (3-morpholin-4-ylpyrazin-2-yl)amine 
• 555-16-8 4-nitrobenzaldehdye 

Relevant articles and documents

Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke-Blackburn-Bienaym reaction and their Hsp90 inhibitory activity

Using a 2,3-diamino pyrazine substrate and yttrium triflate catalyst, various 2-alkyl and aryl substituted 3,8-diaminoimidazo[1,2-a]pyrazines were efficiently prepared through Groebke-Blackburn-Bienaym MCR. In particular, a novel 2-piperonyl 3,8-diaminoimidazo[1,2-a]pyrazine structure was prepared exclusively with this new method and was found to have moderate Hsp90 inhibitory activity. A crystalline complex with N-terminus ATP domain of Hsp90 and one of the new Hsp90 inhibitors was also obtained to elucidate the origin of activity of 2-piperonyl 3,8-diaminoimidazo[1,2-a]pyrazines.