1312611-41-8

Basic information

• Product Name: tert-butyl 6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-ylcarbaMate
• Synonyms: tert-butyl 6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-ylcarbaMate;(6-((tert-Butoxycarbonyl)amino)naphthalen-2-yl)boronic acid pinacol ester;ert-butyl 6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-ylcarbaMate
• CAS NO: 1312611-41-8
• Molecular Formula: C₂₁H₂₈BNO₄
• Molecular Weight: 369.26232
• Mol File: 1312611-41-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: tert-butyl 6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-ylcarbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-ylcarbaMate(1312611-41-8)
• EPA Substance Registry System: tert-butyl 6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-ylcarbaMate(1312611-41-8)

Safety Data

• Hazardous Substances Data: 1312611-41-8(Hazardous Substances Data)

Usage

General Description

Tert-butyl 6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-ylcarbaMate is a chemical compound that is a derivative of naphthalene and contains a boron-containing group. It is typically used as a reagent or intermediate in organic synthesis, particularly in the field of medicinal chemistry and drug development. The tert-butyl group on the nitrogen atom serves as a protecting group, while the boron-containing group can participate in various organic reactions such as Suzuki coupling or direct C-H functionalization. The compound’s unique structure and reactivity make it valuable for the synthesis of complex organic molecules with potential biological activities.

Upstream product

• 869114-68-1 6-bromo-2-N-tert-butoxycarbonylaminonaphthalene 
• 73183-34-3 bis(pinacol)diborane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 7499-66-3 6-Bromonaphthalen-2-amine 
• 5773-80-8 6-bromo-2-naphthoic acid 

Relevant articles and documents

Modular Synthesis of Di- A nd Trisubstituted Imidazoles from Ketones and Aldehydes: A Route to Kinase Inhibitors

A one-pot and modular approach to the synthesis of 2,4(5)-disubstituted imidazoles was developed based on ketone oxidation, employing catalytic HBr and DMSO, followed by imidazole condensation with aldehydes. This methodology afforded twenty-nine disubstituted NH-imidazoles (23%-85% yield). A three-step synthesis of 20 kinase inhibitors was achieved by employing this oxidation-condensation protocol, followed by bromination and Suzuki coupling in the imidazole ring to yield trisubstituted NH-imidazoles (23%-69%, three steps). This approach was also employed in the synthesis of known inhibitor GSK3037619A.

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