7499-66-3Relevant articles and documents
Concise synthesis of 12a-methyl-11-aryl-1,2-dihydrobenzo[f]pyrrolo[1,2-a]quinolin-3(12aH)-ones as racemic 14-azaestrogen analogs
Abdelkhalik, Ashraf M.,Paul, Nawal K.,Jha, Amitabh
, p. 107 - 113 (2015)
A concise method for the synthesis of 14-azasteroid analogs with angular methyl group at C-13 of the steroidal nucleus has been reported in this paper. We have developed an interesting cascade reaction of arylacetylenes and N-(naphthalen-2-yl)pent-4-ynamides under gold (III)-catalysis to produce novel tetracyclic 12a-methyl-11-aryl-1,2-dihydrobenzo[f]pyrrolo[1,2-a]quinolin-3(12aH)-ones which may be viewed as 14-azaestrogen analogs.
Enantioselective Construction of Axially Chiral Amino Sulfide Vinyl Arenes by Chiral Sulfide-Catalyzed Electrophilic Carbothiolation of Alkynes
Ji, Jieying,Jiang, Quanbin,Liang, Yaoyu,Luo, Jie,Zhang, Xiaoyan,Zhao, Xiaodan
supporting information, p. 4959 - 4964 (2020/02/11)
The enantioselective construction of axially chiral compounds by electrophilic carbothiolation of alkynes is disclosed for the first time. This enantioselective transformation is enabled by the use of a Ts-protected bifunctional sulfide catalyst and Ms-protected ortho-alkynylaryl amines (Ts=tosyl; Ms=mesyl). Both electrophilic arylthiolating and electrophilic trifluoromethylthiolating reagents are suitable for this reaction. The obtained products of axially chiral vinyl–aryl amino sulfides can be easily converted into biaryl amino sulfides, biaryl amino sulfoxides, biaryl amines, vinyl–aryl amines, and other valuable difunctionalized compounds.
6-bromo-2-aminonaphthalene preparation method
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Paragraph 0041; 0046; 0047; 0076; 0077; 0078; 0079-0081, (2019/01/08)
The invention provides a 6-bromo-2-aminonaphthalene preparation method. According to the present invention, the easily-available and inexpensive starting materials such as 2-aminonaphthalene, bromine,di-tert-butyl dicarbonate and the like are used; most of the intermediates are not required to be purified and directly enter the next step so as to substantially improve the consistency of the process; the high temperature and high pressure special reaction is not used so as to reduce the production risks; the yields of each reaction are high while the quality of the product meets the requirement; the amount of the three-waste is low so as to reduce the environmental protection pressure of the factory and meet the national conditions; and the product is refined by using the slat forming method so as to substantially improve the purity of the product.
