131271-19-7

Basic information

• Product Name: 4-CHLORO-3-METHYLBENZYL ALCOHOL
• Synonyms: 4-CHLORO-3-METHYLBENZYL ALCOHOL
• CAS NO: 131271-19-7
• Molecular Formula: C₈H₉ClO
• Molecular Weight: 156.61
• Mol File: 131271-19-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-CHLORO-3-METHYLBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-3-METHYLBENZYL ALCOHOL(131271-19-7)
• EPA Substance Registry System: 4-CHLORO-3-METHYLBENZYL ALCOHOL(131271-19-7)

Safety Data

• Hazardous Substances Data: 131271-19-7(Hazardous Substances Data)

Upstream product

• 7697-29-2 4-chloro-3-methylbenzoic acid 

Downstream Products

• 117890-58-1 4-(bromomethyl)-1-chloro-2-methylbenzene 
• 122488-84-0 6-Chloro-9-(4-chloro-3-methyl-benzyl)-2-trifluoromethyl-9H-purine 

Relevant articles and documents

N-SULFONYL BENZAMIDE DERIVATIVE WITH HETEROCYCLIC SUBSTITUENT, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF

The present invention discloses an N-sulfonyl benzamide derivative with a heterocyclic substituent, and a preparation method therefor and a pharmaceutical application thereof. More specifically, the invention discloses a compound represented by formula (II) or a pharmaceutically acceptable salt, stereoisomer, solvent compound, or prodrug thereof, and a preparation method therefor and an application thereof. Refer to the specification for definitions of each group in the formula.

Synthesis and antirhinovirus activity of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)-9H-purines

A series of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)purines was synthesized and tested for antirhinovirus activity. Most of the compounds were synthesized by alkylation of 6-chloro-2-(trifluoromethyl)-9H-purine with the appropriate benzyl halide followed by displacement of the chloro group with dimethylamine. Alternatively, 6-(dimethylamino)-2-(trifluoromethyl)purine was alkylated with the appropriate benzyl halide. Although several different aryl substituents provided compounds with IC50's = 0.03 μM against rhinovirus serotype 1B, no congener was significantly more active than the parent 2. Twenty-three compounds were tested against 18 other serotypes, but none exhibited a uniform profile of activity.