1312756-65-2Relevant academic research and scientific papers
Stereoselective total synthesis of ieodomycin C
Tungen, J?rn E.,Aursnes, Marius,Hansen, Trond Vidar
, p. 3793 - 3797 (2014/05/20)
A concise stereoselective synthesis of the marine natural product ieodomycin C (3) has been achieved from commercially available pyridinium-1-sulfonate (8) in eight linear steps and 14% overall yield. The key synthetic steps included a B-alkyl Suzuki-Miyaura cross-coupling reaction and an Evans-Nagao acetate aldol reaction. The same synthetic sequence was used for preparing the enantiomer of ieodomycin C (3). Our efforts confirmed the structure of the antibacterial natural product 3.
Ieodomycins A-D, antimicrobial fatty acids from a marine Bacillus sp.
Mondol, M. A. Mojid,Kim, Ji Hye,Lee, Min Ah,Tareq, Fakir Shahidullah,Lee, Hyi-Seung,Lee, Yeon-Ju,Shin, Hee Jae
, p. 1606 - 1612 (2011/09/20)
Bioassay-guided isolation of the EtOAc extract of a marine Bacillus sp., cultured in modified Bennett's broth medium, yielded four new antimicrobial fatty acids, named ieodomycins A-D (1-4). The planar structures of these new compounds were determined by extensive 1D and 2D NMR and HRESIMS spectroscopic data analysis. Their absolute configurations were elucidated by modified Mosher's method and literature data review. All four new compounds (1-4) demonstrated antimicrobial activities in vitro.
