1312764-95-6

Basic information

• Product Name: (R)-3-hydroxy-N-(4-methoxybenzyl)pyrrolidine-2,5-dione
• Synonyms: (R)-3-hydroxy-N-(4-methoxybenzyl)pyrrolidine-2,5-dione
• CAS NO: 1312764-95-6
• Molecular Weight: 235.24
• Mol File: 1312764-95-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-3-hydroxy-N-(4-methoxybenzyl)pyrrolidine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-hydroxy-N-(4-methoxybenzyl)pyrrolidine-2,5-dione(1312764-95-6)
• EPA Substance Registry System: (R)-3-hydroxy-N-(4-methoxybenzyl)pyrrolidine-2,5-dione(1312764-95-6)

Safety Data

• Hazardous Substances Data: 1312764-95-6(Hazardous Substances Data)

Upstream product

• 636-61-3 D-Malic acid 
• 2393-23-9 4-methoxy-benzylamine 

Downstream Products

• 622833-72-1 (R)-1-(4-methoxybenzyl)-3-(benzyloxy)pyrrolidine-2,5-dione 
• 536976-73-5 (R)-4-(benzyloxy)-1-(4-methoxybenzyl)pyrrolidin-2-one 
• 1429302-11-3 C₁₃H₁₅NO₄ 
• 1429302-13-5 C₁₇H₂₃NO₄ 
• 1429302-12-4 C₂₂H₃₃NO₆ 

Relevant articles and documents

Intramolecular Mannich and Michael Annulation Reactions of Lactam Derivatives Bearing Enals to Afford Bicyclic N-Heterocycles

Acid-catalyzed intramolecular vinylogous Mannich reactions and intramolecular Michael reactions affording pyrrolizinone-fused N-heterocycles from hydroxylactam derivatives bearing enals have been developed. Depending on the substituent on the hydroxylacta

A study on the racemization step in the synthesis of pyrrolidinols via cyclic α-hydroxyimides

Analytical HPLC methods for the determination of the enantiomeric excess of N-protected malimides 1 as well as the corresponding pyrrolidinol 5 and tartarimides 2 and 3 have been established. On this basis, a study to reveal the racemization step in the synthesis of pyrrolidinols from α-hydroxyacids, via chiral cyclic α-hydroxyimides, has been undertaken. It was confirmed that the known, one-step method for the synthesis of the N-protected chiral cyclic imides from α-hydroxydiacids proceeded with little racemization, and partial racemization has been proven to occur during the reduction of the resultant imide 1a with LAH to yield the corresponding pyrrolidinol 5. Conditions have been defined in order to avoid racemization in the LAH reduction step.