536976-73-5

Upstream product

• 100-39-0 benzyl bromide 
• 622833-72-1 (R)-1-(4-methoxybenzyl)-3-(benzyloxy)pyrrolidine-2,5-dione 
• 108-24-7 acetic anhydride 
• 1312764-95-6 (R)-3-hydroxy-N-(4-methoxybenzyl)pyrrolidine-2,5-dione 
• 536976-89-3 Acetic acid (R)-1-(4-methoxy-benzyl)-5-oxo-pyrrolidin-3-yl ester 
• 536976-90-6 (R)-4-Hydroxy-1-(4-methoxy-benzyl)-pyrrolidin-2-one 

Downstream Products

• 536976-91-7 4-benzyloxy-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 539829-11-3 (R)-4-(benzyloxy)pyrrolidin-2-one 

Relevant academic research and scientific papers

Synthesis of polyhydroxylated quinolizidine and indolizidine scaffolds from sugar-derived lactams via a one-pot reduction/Mannich/Michael sequence

A direct approach to the synthesis of indolizidine and quinolizidine scaffolds of iminosugars is described. The presented strategy is based on a one-pot sugar lactam reduction with Schwartz's reagent followed by a diastereoselective Mannich/Michael tandem reaction of the resulting sugar imine with Danishefsky's diene. The stereochemical course of the investigated reaction has been explained in detail. The obtained bicyclic products are attractive building blocks for the synthesis of various naturally occurring polyhydroxylated alkaloids and their derivatives.

First total synthesis of a new pyrrolizidine alkaloid, amphorogynine A

An efficient and stereodefined strategy is described for the first asymmetric synthesis of a new type of pyrrolizidine alkaloids, amphorogynine A and its 1-epi-isomer. The key 2,4-disubstituted pyrrolidine ring was constructed by elaboration of the chiral