1312775-22-6

Basic information

• Product Name: N-[benzyloxycarbonyl]-L-prolyl-2-methylalanine-N-methyl-N-phenylamide
• Synonyms: N-[benzyloxycarbonyl]-L-prolyl-2-methylalanine-N-methyl-N-phenylamide
• CAS NO: 1312775-22-6
• Molecular Weight: 423.512
• Mol File: 1312775-22-6.mol

Chemical Properties

• CAS DataBase Reference: N-[benzyloxycarbonyl]-L-prolyl-2-methylalanine-N-methyl-N-phenylamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[benzyloxycarbonyl]-L-prolyl-2-methylalanine-N-methyl-N-phenylamide(1312775-22-6)
• EPA Substance Registry System: N-[benzyloxycarbonyl]-L-prolyl-2-methylalanine-N-methyl-N-phenylamide(1312775-22-6)

Safety Data

• Hazardous Substances Data: 1312775-22-6(Hazardous Substances Data)

Upstream product

• 75755-40-7 2,2-dimethyl-3-(N-methyl-N-phenylamino)-2H-azirine 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 

Downstream Products

• 1312775-23-7 N-[benzyloxycarbonyl]-L-prolyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide 
• 1312775-24-8 N-[benzyloxycarbonyl]-L-prolyl-2-methylalanyl-2-methylalanine 
• 1312775-26-0 N-[benzyloxycarbonyl]-L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide 
• 1312775-28-2 L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide 
• 1312775-30-6 N-[benzyloxycarbonyl]-2-methylalanyl-2-methylalanyl-2-methylalanyl-L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide 
• 4598-87-2 N-phenylmethoxycarbonyl-L-prolyl-2-methylalanine 

Relevant articles and documents

Synthesis of poly-aib oligopeptides and aib-containing peptides via the 'azirine/oxazolone method', and their crystal structures

The protected poly-Aib oligopeptides Z-(Aib)n-N(Me)Ph with n=2-6 were prepared according to the 'azirine/oxazolone method', i.e., by coupling amino or peptide acids with 2,2,N-trimethyl-N-phenyl-2H-azirin-3-amine (1a) as an Aib synthon (Schemea 2). Following the same concept, the segments Z-(Aib)3-OH (9) and H-L-Pro-(Aib)3-N(Me)Ph (20) were synthesized, and their subsequent coupling with N,N′- dicyclohexylcarbodiimide (DCC)/ZnCl2 led to the protected heptapeptide Z-(Aib)3-L-Pro-(Aib)3-N(Me)Ph (21; Schemea 3). The crystal structures of the poly-Aib oligopeptide amides were established by X-ray crystallography confirming the 310-helical conformation of Aib peptides.