4598-87-2

Upstream product

• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 1312775-22-6 N-[benzyloxycarbonyl]-L-prolyl-2-methylalanine-N-methyl-N-phenylamide 
• 13257-67-5 2-amino-2-methylpropionic acid methyl ester 
• 78591-29-4 Z-L-Pro-Aib-OMe 

Downstream Products

• 144332-76-3 (S)-2-(4,4-Dimethyl-5-oxo-4,5-dihydro-oxazol-2-yl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 1312775-23-7 N-[benzyloxycarbonyl]-L-prolyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide 
• 1312775-24-8 N-[benzyloxycarbonyl]-L-prolyl-2-methylalanyl-2-methylalanine 
• 1312775-26-0 N-[benzyloxycarbonyl]-L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide 
• 1312775-28-2 L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide 
• 1312775-30-6 N-[benzyloxycarbonyl]-2-methylalanyl-2-methylalanyl-2-methylalanyl-L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide 
• 107169-38-0 O-(1H-benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium tetrafluoroborate 
• 1610040-97-5 C₃₉H₄₇N₅O₈ 
• 1610040-96-4 C₃₉H₄₇N₅O₈ 
• 1610040-84-0 C₁₉H₂₇N₃O₄ 
• 156032-27-8 Z-Pro-Aib-Ala-Aib-Aib-OMe 
• 82427-27-8 methyl N-4-chlorobenzoyl-L-prolyl-2-methylalanyl-L-alanyl-2-methylalanyl-L-alaninate 

Relevant academic research and scientific papers

Synthesis of poly-aib oligopeptides and aib-containing peptides via the 'azirine/oxazolone method', and their crystal structures

The protected poly-Aib oligopeptides Z-(Aib)n-N(Me)Ph with n=2-6 were prepared according to the 'azirine/oxazolone method', i.e., by coupling amino or peptide acids with 2,2,N-trimethyl-N-phenyl-2H-azirin-3-amine (1a) as an Aib synthon (Schemea 2). Following the same concept, the segments Z-(Aib)3-OH (9) and H-L-Pro-(Aib)3-N(Me)Ph (20) were synthesized, and their subsequent coupling with N,N′- dicyclohexylcarbodiimide (DCC)/ZnCl2 led to the protected heptapeptide Z-(Aib)3-L-Pro-(Aib)3-N(Me)Ph (21; Schemea 3). The crystal structures of the poly-Aib oligopeptide amides were established by X-ray crystallography confirming the 310-helical conformation of Aib peptides.

Fungal metabolites. IX. Synthesis of a membrane-modifying peptide, hypelcin A-III, from Hypocrea peltata

A membrane-modifying peptide antibiotic having uncoupling activity on rat liver mitochondria, hypelcin A-III, has been synthesized by assembling five peptide fragments via the N,N'-dicyclohexylcarbodiimide method. The synthesized hypelcin A-III was identi

THE CHEMISTRY OF PEPTIDES RELATED TO METABOLITES OF TRICHODERMA SPP. 2. AN IMPROVED METHOD OF CHARACTERIZATION OF PEPTIDES OF 2-METHYLALANINE

4-Chlorobenzoylazide reacts with amino acid and peptide esters to give the 4-chlorobenzoyl derivatives in 60-90percent yield, at room temperature, without measurable racemization.The reaction also proceeds smoothly with hindered amines such as methyl 2-me