1312778-71-4

Upstream product

• 123077-62-3 ethyl (S)-2-(trityloxy)propionate 
• 76-83-5 trityl chloride 
• 1312778-67-8 allyl (E,5S)-4-hydroxy-5-(trityloxy)hex-2-enoate 
• 1312778-66-7 allyl (E,5S)-4-hydroxy-5-(trityloxy)hex-2-enoate 
• 1312778-64-5 dimethyl (S)-2-oxo-3-(trityloxy)butylphosphonate 
• 1312778-70-3 allyl (E,4R,5S)-5-(hydroxy)-4-(methoxymethoxy)hex-2-enoate 
• 1312778-69-0 (E,4R,5S)-4-(methoxymethoxy)-5-(trityloxy)hex-2-enoic acid 
• 1312778-68-9 allyl (E,4R,5S)-4-(methoxymethoxy)-5-(trityloxy)hex-2-enoate 

Downstream Products

• 172923-77-2 (+)-macrosphelide A 

Relevant academic research and scientific papers

Enantioselective total synthesis of macrosphelides A and e

Enantioselective synthesis of 16-membered trilactone macrolides, macrosphelide A and E from (S)-lactic acid is described. Key features of the synthesis include the utility of a hitherto unexplored β-ketophosphonate derived from lactic acid and Yamaguchi lactonization leading to the title compounds.