1312794-14-1Relevant articles and documents
Design, synthesis, and diversification of 3,5-substituted enone library
Khalaf, Juhienah,Estrella-Jimenez, Maria E.,Shashack, Matthew J.,Phatak, Sharangdhar S.,Zhang, Shuxing,Gilbertson, Scott R.
scheme or table, p. 351 - 356 (2011/08/21)
This paper describes the synthesis of a 300 member library of 3,5-substituted enones. The synthesis starts with 6 different bromoenones that are accessed from the corresponding 1,3 diones. These bromides are then diversified by Suzuki coupling with a variety of aromatic and vinyl boronic acids. Additionally a small series of triazoles was synthesized by a Sonogashira coupling reaction dipolar cycloaddition sequence. The library was analyzed by principal component analysis to examine its diversity.
