131288-27-2

Upstream product

• 133871-25-7 benzyl (R)-2-allyl-3-phenylpropanoate 
• 201230-82-2 carbon monoxide 
• 95176-68-4 phenylmethyl α-methylenebenzenepropanoate 
• 501-52-0 3-Phenylpropionic acid 
• 205373-70-2 (2'R,4R)-N-(2'-allyl-3'phenylpropanoyl)-4-benzyl-1,3-oxazolidin-2-one 
• 92576-42-6 2-benzyl-pent-4-enoyl chloride 
• 6540-96-1 2-benzyl-4-pentenoic acid 

Relevant academic research and scientific papers

Rhodium-Catalyzed Enantioselective Anti-Markovnikov Hydroformylation of α-Substituted Acryl Acid Derivatives

Rhodium-catalyzed asymmetric anti-Markovnikov hydroformylation of α-substituted acrylates/acrylamides has been developed. By employing the Rh/(S,S)-DTBM-YanPhos complex, a series of β-chiral linear aldehydes were obtained in high yields (up to 94% yield) and high enantioselectivities (up to 96% ee). The utility of this methodology is demonstrated by a gram-scale reaction and a concise synthetic route to chiral ?3-butyrolactone.

Stereochemistry in enzyme inhibition: Synthesis and evaluation of enantiomerically pure 2-benzyl-3-formylpropanoic acids as inhibitors of carboxypeptidase A

Both enantiomers of 2-benzyl-3-formylpropanoic acid were synthesized in five steps starting with hydrocinnamic acid and each enantiomer assayed for inhibitory activity against carboxypeptidase A to find that the (R)-form is 674-fold more potent than its e

HETEROCYCLIC PEPTIDE RENIN INHIBITORS

A renin inhibiting compound of the formula STR1 wherein X is N, O or CH; R 1 is absent or a functional group; A and L are independently selected from absent, C=O, SO 2 and CH 2 ; D is C=O, SO. sub.2 or CH 2 ; Y is N or CH; R 2 is hydrogen, loweralkyl or substituted alkyl; Z is a functional group; R 3 is loweralkyl or substituted alkyl; n is 0 or 1; and T is a mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof.