92576-42-6

Upstream product

• 82044-44-8 diethyl benzyl(prop-2'-en-1'-yl)propanedioate 
• 6540-96-1 2-benzyl-4-pentenoic acid 
• 501-52-0 3-Phenylpropionic acid 

Downstream Products

• 116632-86-1 2-benzyl-pent-4-enoic acid-(4-nitro-anilide) 
• 102177-34-4 2-benzyl-pent-4-enoic acid benzylamide 
• 7154-69-0 2-benzylpent-4-enamide 
• 205373-70-2 (2'R,4R)-N-(2'-allyl-3'phenylpropanoyl)-4-benzyl-1,3-oxazolidin-2-one 
• 255915-27-6 (2'S,4R)-N-(2'-allyl-3'phenylpropanoyl)-4-benzyl-1,3-oxazolidin-2-one 
• 52784-33-5 5-Benzyl-2-cyclopenten-1-on 
• 125016-04-8 benzyl (S)-2-allyl-3-phenylpropanoate 
• 133871-25-7 benzyl (R)-2-allyl-3-phenylpropanoate 
• 131288-47-6 benzyl (R)-2-benzyl-3-formylpropanoate 
• 131288-27-2 benzyl (S)-2-benzyl-3-formylpropanoate 
• 21307-97-1 (R)-2-benzylsuccinic acid 

Relevant academic research and scientific papers

Intramolecular formal [4+2] cycloaddition of 3-ethoxycyclobutanones and alkenes

Intramolecular formal [4+2] cycloaddition between 3-ethoxycyclobutanones and a carbon-carbon double bond to the corresponding bicyclo[4.n.0]alkan-2-one derivatives proceeded effectively by using ethylaluminium dichloride. The Royal Society of Chemistry 20

Trialkylamine-mediated intramolecular acylation of akenes with carboxylic acid chlorides

Trialkylamine-mediated intramolecular cyclization of pent-4-enoyl chlorides was studied. Substitution with a tertiary alkyl group at the 2-position gave cyclopent-2-en-1-ones, while substitution with an aromatic group gave enol esters, which were formed by O-acylation of initially formed 3-chlorocyclopentanones with ketenes.

Stereochemistry in enzyme inhibition: Synthesis and evaluation of enantiomerically pure 2-benzyl-3-formylpropanoic acids as inhibitors of carboxypeptidase A

Both enantiomers of 2-benzyl-3-formylpropanoic acid were synthesized in five steps starting with hydrocinnamic acid and each enantiomer assayed for inhibitory activity against carboxypeptidase A to find that the (R)-form is 674-fold more potent than its e

SAR of 2-benzyl-4-aminopiperidines NK1 antagonists. Part 2. Synthesis of CGP 49823

CGP 49823 is a potent NK1 antagonist which is centrally active after oral administration. The SAR of the C-2 substituent was investigated with respect to the affinity to the NK1 receptor. A practical synthesis of CGP 49823, suitable for scale-up, was developed. The key-step, a tandem acyliminium ion cyclization/Ritter reaction, gave trans-2-benzyl-4-acetamido-piperidines with high diastereoselectivity.