1312924-02-9

Usage

Uses

Used in Pharmaceutical Industry:
3-(2-(pyridin-2-yl)ethynyl)-5-iodobenzonitrile is used as a key intermediate in the synthetic preparation of 3,5-disubstituted thiazolylethynyland pyridinylethynylbenzenes. These compounds have been identified as potent mGluR5 antagonists, which are important in the development of drugs targeting various neurological disorders and conditions. The antagonistic properties of these compounds make them valuable for research and therapeutic applications in the treatment of diseases such as Fragile X syndrome, schizophrenia, and chronic pain.

Upstream product

• 97165-77-0 3,5-dibromobenzonitrile 
• 1595030-89-9 3-bromo-5-(pyridine-2-ylethynyl)benzonitrile 
• 1595030-95-7 3-tributylstannyl-5-(2-pyridinylethynyl)benzonitrile 
• 1945-84-2 2-ethynylpyridine 

Relevant academic research and scientific papers

Radiosynthesis of SPECT tracers: Via a copper mediated 123I iodination of (hetero)aryl boron reagents

A general method for the copper mediated nucleophilic 123I-iodination of (hetero)aryl boronic esters and acids has been developed. The broad substrate scope of this radiosynthetic approach allows access to [123I]DPA-713, [123I]IMPY, [123I]MIBG and [123I]IPEB that are four commonly used SPECT radiotracers. Our results infer that aryl boronic reagents can now be employed as common precursors for both fluorine-18 and iodine-123 radiolabelling.

IODINE(III)-MEDIATED RADIOFLUORINATION

A process for fluorination of aromatic compounds employing iodonium ylides and applicable to radiofluorination using 18F is described. Processes, intermediates, reagents and radiolabelled compounds are described.

Development of [123I]IPEB and [123I]IMPEB as SPECT Radioligands for Metabotropic Glutamate Receptor Subtype 5

mGlu5 play an important role in physiology and pathology to various central nervous system (CNS) diseases. Several positron emission tomography (PET) radiotracers have been developed to explore the role of mGlu5 in brain disorders. H