1595030-95-7Relevant academic research and scientific papers
Copper-Mediated Radiofluorination of Arylstannanes with [18F]KF
Makaravage, Katarina J.,Brooks, Allen F.,Mossine, Andrew V.,Sanford, Melanie S.,Scott, Peter J. H.
supporting information, p. 5440 - 5443 (2016/11/04)
A copper-mediated nucleophilic radiofluorination of aryl- and vinylstannanes with [18F]KF is described. This method is fast, uses commercially available reagents, and is compatible with both electron-rich and electron-deficient arene substrates. This method has been applied to the manual synthesis of a variety of clinically relevant radiotracers including protected [18F]F-phenylalanine and [18F]F-DOPA. In addition, an automated synthesis of [18F]MPPF is demonstrated that delivers a clinically validated dose of 200 ± 20 mCi with a high specific activity of 2400 ± 900 Ci/mmol.
Development of [123I]IPEB and [123I]IMPEB as SPECT Radioligands for Metabotropic Glutamate Receptor Subtype 5
Kil, Kun-Eek,Zhu, Aijun,Zhang, Zhaoda,Choi, Ji-Kyung,Kura, Sreekanth,Gong, Chunyu,Brownell, Anna-Liisa
, p. 652 - 656 (2014/07/07)
mGlu5 play an important role in physiology and pathology to various central nervous system (CNS) diseases. Several positron emission tomography (PET) radiotracers have been developed to explore the role of mGlu5 in brain disorders. H
