1312929-68-2Relevant academic research and scientific papers
Silver/ThioClickFerrophos complex as an effective catalyst for asymmetric conjugate addition of glycine imino ester to unsaturated malonates and α-enones
Konno, Takashi,Watanabe, Sayo,Takahashi, Tatsuki,Tokoro, Yuichiro,Fukuzawa, Shin-Ichi
supporting information, p. 4418 - 4421 (2013/09/24)
The AgOAc/ThioClickFerrophos complex effectively catalyzed the conjugate addition of glycine imino esters to arylidene and alkylidene malonates, furnishing the corresponding adducts in good yields with high enantioselectivities, in the presence or absence of an external base. The complex also catalyzed conjugate addition to α-enones in the presence of 1,4-diazabicyclo[2.2.2]octane with high enantioselectivity, with formation of a small amount of cycloadducts.
Enantiocontrolled synthesis of β-branched α-amino acids by using CuI-catalyzed 1,4-addition of glycine imines to β-substituted gem-diactivated olefins
Hernandez-Toribio, Jorge,Arrayas, Ramon Gomez,Carretero, Juan C.
supporting information; experimental part, p. 6334 - 6337 (2011/08/06)
Branching out! The catalytic asymmetric conjugate addition of glycinate Schiff bases to β-substituted gem-diactivated Michael acceptors under proton transfer conditions gives a variety of β-branched α-amino acids (see scheme; Dpm=diphenylmethylene, EWG=electron-withdrawing group) with excellent levels of diastereo- (typically syn/anti >90:10) and enantiocontrol (90-99 % ee). Copyright
