1312937-41-9

Basic information

• Product Name: Erlotinib IMpurity C
• Synonyms: Erlotinib IMpurity C
• CAS NO: 1312937-41-9
• Molecular Formula: C₁₅H₂₀N₂O₅
• Molecular Weight: 308.3297
• EINECS: -0
• Mol File: 1312937-41-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Erlotinib IMpurity C(CAS DataBase Reference)
• NIST Chemistry Reference: Erlotinib IMpurity C(1312937-41-9)
• EPA Substance Registry System: Erlotinib IMpurity C(1312937-41-9)

Safety Data

• Hazardous Substances Data: 1312937-41-9(Hazardous Substances Data)

Usage

Uses

4-Methoxy-6,7-bis(2-methoxyethoxy)quinazoline?is an impurity of?Erlotinib?(E625000), a selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor.

Upstream product

• 1312937-40-8 4-methoxyquinazoline-6,7-diol 
• 6482-24-2 2-Bromoethyl methyl ether 
• 179688-29-0 6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one 
• 67-56-1 methanol 
• 4101-33-1 6,7-dimethoxy-N,N-quinazoline 
• 16064-15-6 6,7-dihydroxyquinazolin-4(3H)-one 
• 183322-18-1 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline 

Downstream Products

• 183319-69-9 erlotinib hydrochloride 
• 183321-74-6 erlotinib 

Relevant articles and documents

Preparation process of erlotinib

Preparation process of erlotinib or its salts comprising: reacting 6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline with 3-ethynylaniline or a salt thereof in the presence of a base and a reaction-inert solvent, and optionally, treating the compound obtained with a pharmaceutically acceptable acid to form the corresponding pharmaceutically acceptable salt. The compound 6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline can be prepared either from 4-methoxyquinazoline-6,7-diol or 6,7-bis(2-methoxyethoxy)quinazolinone. The compounds 6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline and 4-methoxyquinazoline-6,7-diol are new intermediates useful for the preparation of erlotinib or its salts.