1312938-57-0Relevant articles and documents
Concise, convergent syntheses of (±)-trichostatin a utilizing a Pd-catalyzed ketone enolate α-alkenylation reaction
Cosner, Casey C.,Helquist, Paul
, p. 3564 - 3567 (2011)
Two concise, convergent syntheses of (±)-trichostatin A (1), a potent histone deacetylase inhibitor, have been accomplished. The key step in both is a Pd-catalyzed α-alkenylation reaction between ketone 2 and either dienyl bromide 3 or alkenyl bromide 9 u