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114127-17-2

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114127-17-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 114127-17-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,1,2 and 7 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 114127-17:
(8*1)+(7*1)+(6*4)+(5*1)+(4*2)+(3*7)+(2*1)+(1*7)=82
82 % 10 = 2
So 114127-17-2 is a valid CAS Registry Number.
InChI:InChI=1/C17H21NO3/c1-12(5-10-16(19)20)11-13(2)17(21)14-6-8-15(9-7-14)18(3)4/h5-11,13H,1-4H3,(H,19,20)/b10-5+,12-11+

114127-17-2Relevant articles and documents

Disappearance of differentiation-induction of friend leukemia cells upon racemization of trichostatic acid

Morioka,Ishihara,Takezawa,Shibai,Komoda

, p. 583 - 584 (1988)

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SYNTHESIS OF HDAC INHIBITORS: TRICHOSTATIN A AND ANALOGUES

-

, (2011/10/12)

Embodiments herein relate to histone deacetylaces (HDACs) and HDAC inhibitors, such as trichostatin A (TSA) and TSA analogues. Embodiments provide simple methods of synthesizing TSA and TSA analogues. These methods provide routes of synthesis of TSA and TSA analogues that enable the production of the HDAC inhibitors at lower cost and in greater quantities than previously were available.

Synthesis of 4-methyldienoates using a vinylogous horner-wadsworth-emmons reagent. application to the synthesis of trichostatic acid

Markiewicz, John T.,Schauer, Douglas J.,Loefstedt, Joakim,Corden, Steven J.,Wiest, Olaf,Helquist, Paul

supporting information; experimental part, p. 2061 - 2064 (2010/06/16)

Chemical Equation Presented The utility of the unsaturated phosphonate 1 as a vinylogous Horner-Wadsworth-Emmons reagent was explored in reactions with, aldehydes affording 4-methyldienoate esters. Factors that affect E/Z selectivity were studied. A simplified synthesis of trichostatic acid 3 was accomplished, to demonstrate utility of this reagent.

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