131294-12-7Relevant articles and documents
Magnesium-catalyzed asymmetric direct aldol addition of ethyl diazoacetate to aromatic, aliphatic, and α,β-unsaturated aldehydes
Trost, Barry M.,Malhotra, Sushant,Fried, Benjamin A.
supporting information; experimental part, p. 1674 - 1675 (2009/07/25)
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Inter- and intramolecular Mitsunobu reaction based approaches to 2-substituted chromans and chroman-4-ones
Hodgetts, Kevin J.
, p. 6860 - 6870 (2007/10/03)
Two approaches to optically active 2-substituted chromans and chroman-4-ones are described. The first utilized an intermolecular Mitsunobu reaction of a homochiral halopropanol and 2-bromophenol followed by cyclization to the 2-substituted chroman. In addition, a double lithiation procedure was developed to introduce additional functionality to the chroman. The second approach utilized an intramolecular Mitsunobu cyclization to give the 2-substituted chroman-4-one nucleus. The methodologies were applied to the syntheses of several biologically active natural and synthetic products.