131298-20-9Relevant academic research and scientific papers
Enzyme-Catalyzed Reactions, 8. - Stereoselective Synthesis of 2-Amino Alcohols from (R)- and (S)-Cyanohydrins
Effenberger, Franz,Gutterer, Beate,Ziegler, Thomas
, p. 269 - 273 (2007/10/02)
erythro-2-Amino alcohols (1R,2S)- and (1S,2R)-4 may be synthesized stereoselectively by addition of Grignard compounds to cyanohydrins (R)-, (S)-1 and their O-trimethylsilyl derivatives 3, respectively, followed by hydrogenation.The threo-2-amino alcohols (1S,2S)- and (1R,2R)-4 are easily accessible by inversion at C-1 of the (1R,2S) and (1S,2R) compounds.
