1312992-62-3Relevant academic research and scientific papers
A chemoselective Ugi-type reaction in water using TMSCN as a functional isonitrile equivalent: Generation of heteroaromatic molecular diversity
Guchhait, Sankar Kumar,Chaudhary, Vikas,Madaan, Chetna
, p. 9271 - 9277,7 (2012/12/12)
KF-mediated nucleophilic activation of TMSCN as a functional isonitrile equivalent establishes an efficient and chemoselective Ugi-type multicomponent reaction of a heterocyclic amidine and aldehyde with TMSCN in water. In this approach, the use of isocyanide is circumvented, known competing reactions are virtually eliminated, pure products are obtained by a non-chromatographic method, and therapeutically relevant and diverse N-fused 3-aminoimidazoles can be prepared from a wide variety of aldehydes and heterocyclic amidines. This reaction coupling with cascade cyclization provides various privileged tetracyclic heteroaromatic scaffolds.
N-fused imidazoles as novel anticancer agents that inhibit catalytic activity of topoisomerase IIα and induce apoptosis in G1/S phase
Baviskar, Ashish T.,Madaan, Chetna,Preet, Ranjan,Mohapatra, Purusottam,Jain, Vaibhav,Agarwal, Amit,Guchhait, Sankar K.,Kundu, Chanakya N.,Banerjee, Uttam C.,Bharatam, Prasad V.
, p. 5013 - 5030 (2011/10/02)
On the basis of structures of known topoisomerase II catalytic inhibitors and initial molecular docking studies, bicyclic N-fused aminoimidazoles were predicted as potential topoisomerase II inihibitors. They were synthesized by multicomponent reactions a
