1313036-56-4

Basic information

• Product Name: 2-chloro-4-(3-nitrophenoxy)pyrrolo[2,1-f][1,2,4]triazine
• Synonyms: 2-chloro-4-(3-nitrophenoxy)pyrrolo[2,1-f][1,2,4]triazine
• CAS NO: 1313036-56-4
• Molecular Weight: 290.666
• Mol File: 1313036-56-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-chloro-4-(3-nitrophenoxy)pyrrolo[2,1-f][1,2,4]triazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-(3-nitrophenoxy)pyrrolo[2,1-f][1,2,4]triazine(1313036-56-4)
• EPA Substance Registry System: 2-chloro-4-(3-nitrophenoxy)pyrrolo[2,1-f][1,2,4]triazine(1313036-56-4)

Safety Data

• Hazardous Substances Data: 1313036-56-4(Hazardous Substances Data)

Upstream product

• 918538-04-2 pyrrolo[2,1-f][1,2,4]triazine-2,4(1H, 3H)-dione 
• 1379337-32-2 1-(ethoxyformamido)-1H-pyrrole-2-carboxamide 
• 159326-69-9 1-aminopyrrole-2-carboxamide 
• 159326-66-6 N-amino-1H-pyrrole-2-carbonitrile 
• 918538-05-3 2,4-dichloro-pyrrolo[2,1-f][1,2,4]triazine 
• 554-84-7 meta-nitrophenol 

Downstream Products

• 1313036-57-5 N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-4-(3-nitrophenoxy)pyrrolo[2,1-f][1,2,4]triazin-2-amine 
• 1313036-58-6 4-(3-aminophenoxy)-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-amine 
• 1313036-44-0 N-(3-((2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrrolo[2,1-f][1,2,4]triazin-4-yl)oxy)phenyl)acrylamide 

Relevant articles and documents

Synthesis and medical application of pyrrolo-[2,1-f] [1,2,4] triazine mother nucleus compound

The invention discloses a synthesis and medical application of pyrrolo-[2,1-f] [1,2,4] triazine mother nucleus compound. The compound belongs to a novel-structure compound. The synthesis method is high in operating safety, mild in reaction condition and suitable for industrial production. The activity and the selectivity of BTK kinase and the in-vitro proliferation activity of a leukemia cell line are test, it is verified that the compound has the selective and irreversible inhibition effect on the BTK kinase, and has the different-degree inhibition effect on leukemia cells. According to measurement, the compound also has the good anti-arthritic activity on a collagen-induced arthritis (rCIA) model. The pyrrolo-[2,1-f] [1,2,4] triazine mother nucleus compound can be used for preparing medicine for treating arthritis and leukemia.