1313046-73-9

Upstream product

• 942133-13-3 (2R,3S,E)-((1R,2S)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 3-hydroxy-5-iodo-2,4-dimethylpent-4-enoate 
• 1180131-47-8 (1R,2S)-2-[benzyl(mesitylsulfonyl)amino]-1-phenylpropyl-(2R,3S,4E)-5-iodo-2,4-dimethyl-3-[(triethylsilyl)oxy]pent-4-enoate 
• 1313046-59-1 (2S,3S,4E)-5-iodo-2,4-dimethyl-3-[(triethylsilyl)oxy]pent-4-en-1-ol 
• 1313046-61-5 (2R,3S,4E)-5-iodo-2,4-dimethyl-3-[(triethylsilyl)oxy]pent-4-enal 
• 1313046-63-7 methyl (3R,6R,8E,10S,11S,12E)-3-{[tert-butyl(dimethyl)silyl]oxy}-13-iodo-6-[(2-methoxyethoxy)methoxy]-6,10,12-trimethyl-7-oxo-11-[(triethylsilyl)oxy]trideca-8,12-dienoate 
• 1313046-65-9 (3R,6R,8E,10S,11S,12E)-3-{[tert-butyl(dimethyl)silyl]oxy}-13-iodo-6-[(2-methoxyethoxy)methoxy]-6,10,12-trimethyl-7-oxo-11-[(triethylsilyl)oxy]trideca-8,12-dienoic acid 
• 1313046-71-7 C₂₆H₄₇IO₇Si 
• 960-16-7 tributylphenylstannane 
• 1313046-38-6 (3R)-3-[(2-methoxyethoxy)methoxy]-3,7-dimethylocta-1,6-diene 
• 1313046-40-0 (6R)-6-[(2-methoxyethoxy)methoxy]-2,6-dimethyloct-7-ene-2,3-diol 
• 1313046-42-2 (4R)-4-[(2-methoxyethoxy)methoxy]-4-methylhex-5-enal 
• 1313046-45-5 (4R)-3-{(3'R,6'R)-3'-hydroxy-6'-[(2-methoxyethoxy)methoxy]-6'-methyloct-7'-enoyl}-4-isopropyl-1,3-thiazolidine-2-thione 
• 1313046-47-7 (4R)-3-{(3'R,6'R)-3'-{[tert-butyl(dimethyl)silyl]oxy}-6'-[(2-methoxyethoxy)methoxy]-6'-methyloct-7'-enoyl}-4-isopropyl-1,3-thiazolidine-2-thione 
• 1313046-49-9 methyl (3R,6R)-3-{[tert-butyl(dimethyl)silyl]oxy}-6-[(2-methoxyethoxy)methoxy]-6-methyloct-7-enoate 

Downstream Products

• 1313046-75-1 C₃₄H₅₄O₈Si 

Relevant academic research and scientific papers

Synthesis of pladienolide b and its 7-epimer with insights into the role of the allylic acetate

Diastereomeric macrolactones 41 and 48, which are epimeric at C-7, were both prepared by a synthesis based on our previously developed route to the macrolactone core of pladienolide B. Both compounds contain all the functionality of the macrolactone core

Synthesis of a pladienolide B analogue with the fully functionalized core structure

Starting from (R)-(-)-linalool (6), terminus differentiation and chain extension via aldol type reactions led to ketophosphonate 16 (C1-C8 building block). In a Horner-Wadsworth-Emmons reaction, 16 reacted with aldehyde 22, which contained the vicinal ant