1313238-82-2Relevant academic research and scientific papers
Synthesis, characterization, and biological activity of some aza-uracil derivatives
El-Barbary, Ahmed Ahmed,Hafiz, Yehia Ahmed,Abdel-Wahed, Mohamed Shaker
, p. 639 - 644 (2011/07/31)
Thiation of 1 by LR gave the corresponding 3,5-dithioxo derivative 2 and the trimer 3. Methylation of 1 afforded the S-methyl derivative 4. Compound 1 was fused with 6-bromo-2-phenyl-benzo[1,3-d]oxazin-4-one (5) and gave 6. Condensation of 1 with some acid derivatives 7a-d and/or 8a-c yielded thiadiazolo-triazine derivatives 9a-d and 10a-c. Compounds 9a,c and 10c were hydrolyzed to furnish 11a-c. Acetylation of 14 afforded mono- and diacetyl-derivatives 15 and 16. Benzoylation of 14 afforded mono- and dibezoyl-derivatives 17 and 18. 14 with some aromatic aldehydes yielded 19a-c. Reacting 14 with phenyl (iso- and/or isothio-) cyanate gave the urea derivatives 20a,b. Thiation of 14 with P4S10 furnished 21. The newly synthesized compounds were tested as antimicrobial agents.
