131326-87-9

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 78373-76-9 6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-4-isochinolon 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 78373-65-6 N-(3,4-dimethoxybenzyl)-N-methyl-2,2-diethoxyethylamine 
• 32871-88-8 N-(3,4-dimethoxybenzyl)aminoacetaldehyde diethyl acetal 
• 58163-19-2 dimethoxy-3,4 benzylideneaminoacetal diethylique 
• 19373-83-2 (+/-)dimethoxy-6,7 methyl-2 hydroxy-4 tetrahydro-1,2,3,4 isoquinoleine 
• 140843-30-7 4,5-dimethoxy-2-iodo-N-methylbenzylamine 
• 72785-34-3 2-bromo-4,5-dimethoxy-N-methyl-benzylamine 
• 61203-53-0 2-iodo-4,5-dimethoxybenzaldehyde 
• 131326-76-6 2-[(2-Iodo-4,5-dimethoxy-benzyl)-methyl-amino]-1-(4-methoxy-phenyl)-ethanone 
• 131326-85-7 2-[(2-Bromo-4,5-dimethoxy-benzyl)-methyl-amino]-1-(4-methoxy-phenyl)-ethanone 

Downstream Products

• 23330-76-9 6,7-dimethoxy-4-(4-methoxyphenyl)-2-methyl-1, 2, 3, 4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

A convenient synthesis of 4-substituted 1,2,3,4-tetrahydroisoquinolin-4-ols by a novel intramolecular Barbier reaction and by an insertion reaction: Reaction scope and limitations

4-Substituted 1,2,3,4-tetrahydroisoquinolin-4-ols were prepared from N-(2-iodobenzyl)phenacylamines by an intramolecular Barbier reaction with butyllithium and by an insertion reaction with zerovalent nickel. The scope and limitations of these reactions were discussed.

A NEW INTRAMOLECULAR BARBIER REACTION OF N-(2-IODOBENZYL)PHENACYLAMINES: A CONVENIENT SYNTHESIS OF 1,2,3,4-TETRAHYDROISOQUINOLIN-4-OLS

4-Phenyl-1,2,3,4-tetrahydroisoquinolin-4-ols were prepared by an intramolecular Barbier reaction of N-(2-iodobenzyl)phenacylamines with butyllithium in good yields.

Etude de l'oxydation de tetrahydroisoquinoleinols-4 dimethoxyles en 6,7 ou 7,8, et sur la reactivite du carbonyle de la tetrahydroisoquinolone-4 dimethoxylee en 6,7

Preparation des tetrahydroisoquinoleinols-4 mentionnes ci-dessus, et etude de l'oxydation de ceux-ci au moyen de divers reactifs: oxydations chromiques, par les bromamides, le dimethylsulfoxide, la reaction d'Oppenauer.Seule cette derniere a conduit aux t