13134-11-7Relevant articles and documents
Knoevenagel condensation catalyzed by novel Nmm-based ionic liquids in water
Xu, Hao,Pan, Liyang,Fang, Xiaomin,Liu, Baoying,Zhang, Wenkai,Lu, Minghua,Xu, Yuanqing,Ding, Tao,Chang, Haibo
, p. 2360 - 2365 (2017)
A series of novel N-methyl morpholine (Nmm) based ionic liquids with 1,2-propanediol group were synthesized and used as catalysts for Knoevenagel condensation at room temperature in water. Under the effect of the catalyst, various aldehydes or aliphatic ketones could react with a wide range of activated methylene compounds well, including malononitrile, alkyl cyanoacetate, cyanoacetamide, β-diketone, barbituric acid, 2-arylacetonitrile and thiazolidinedione. Furthermore, most of the products could be separated just by filtrating and washing with water. Additionally, the catalyst is recyclable and applicable for the large-scale synthesis.
A convenient and selective one-pot method for the synthesis of monosubstituted secondary alkyl malononitriles
Sammelson, Robert E.,Allen, Mark J.
, p. 543 - 546 (2007/10/03)
We have found that α,α-dicyanoalkenes can be efficiently and selectively reduced to α,α-dicyanoalkanes (malononitriles) with NaBH4 in 95% EtOH at 0 °C. In addition, we have determined that the condensation of malononitrile with ketones using absorption alumina as a catalyst can be followed directly, in one pot, by reduction with NaBH 4 in 95% EtOH at 0 °C to provide the monosubstituted secondary alkyl malononitriles in good to excellent yields (42-94%). This procedure provides a convenient alternative to direct alkylation of malononitrile or reduction of α,α-dicyanoalkene intermediates.
Iminoformylation Reaction of Substituted Crotonnitriles. II. On the Reaction of Ylidenmalononitriles with Formamide Acetals in the Presence of Acetic Acid
Koeckritz, P.,Schmidt, L.,Liebscher, J.
, p. 150 - 156 (2007/10/02)
-
