1313513-07-3

Upstream product

• 88352-90-3 aminomethyl 3-furyl ketone hydrochloride 
• 3336-16-1 2-chloro-4-hydroxybenzonitrile 
• 1313512-95-6 2-(2-chloro-4-ethoxy-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)acetic acid 
• 1259020-46-6 5-bromo-2-chloro-4-hydroxybenzonitrile 
• 1313512-88-7 (5-bromo-2-chloro-4-ethoxybenzyloxy)triisopropylsilane 

Relevant academic research and scientific papers

THIAZOLE DERIVATIVES AS SGLT2 INHIBITORS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present invention relates to a novel compound with thiazole ring having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes.

Thiazolylmethyl ortho-substituted phenyl glucoside library as novel C-aryl glucoside SGLT2 inhibitors

In order to investigate SAR regarding proximal phenyl ring in novel C-aryl glucoside SGLT2 inhibitors containing a thiazole motif, a series of chemical modifications on proximal phenyl ring was conducted. During a series of lead optimization efforts, orth