1313592-32-3

Upstream product

• 5619-07-8 methyl 2-amino-3-phenylpropanoate hydrochloride 
• 1313592-28-7 C₂₁H₂₆N₂O₂ 
• 700-58-3 2-Adamantanone 

Downstream Products

• 1313592-52-7 C₂₉H₃₃N₃O₄ 
• 1313592-20-9 (R,S)-N-hydroxy-3,5-dioxo-6-(phenylmethyl)spiro[piperazine-2,2'-tricyclo[3.3.1.13,7]decane]-4-acetamide 
• 1313592-93-6 (R,S)-N-hydroxy-3,5-dioxo-6-(phenylmethyl)spiro[piperazine-2,2'-tricyclo[3.3.1.13,7]decane]-4-acetamide hydrochloride 
• 1313592-42-5 C₂₂H₂₆N₂O₄ 
• 1313592-57-2 C₂₀H₂₄N₂O₂ 
• 1313592-35-6 C₂₉H₃₂N₂O₄ 

Relevant academic research and scientific papers

Novel lipophilic acetohydroxamic acid derivatives based on conformationally constrained spiro carbocyclic 2,6-diketopiperazine scaffolds with potent trypanocidal activity

We describe novel acetohydroxamic acid derivatives with potent activity against cultured bloodstream-form Trypanosoma brucei and selectivity indices of >1000. These analogues were derived from conformationally constrained, lipophilic, spiro carbocyclic 2,6-diketopiperazine (2,6-DKP) scaffolds by attaching acetohydroxamic acid moieties to the imidic nitrogen. Optimal activity was achieved by placing benzyl groups adjacent to the basic nitrogen of the 2,6-DKP core. S-Enantiomer 7d was the most active derivative against T. brucei (IC50 = 6.8 nM) and T. cruzi (IC50 = 0.21 μM).