13136-17-9Relevant academic research and scientific papers
Synthesis of lipoxygenase inhibitors. Part 1: Synthesis of open amidrazones
Nuhn,Buge,Harenberg,Lettau,Moschner,Rauchmaul,Schneider
, p. 340 - 342 (2007/10/02)
The synthesis of some amidrazones as bioisosteric diazaallyl radicals is described starting from the reaction mechanism of the lipoxygenases which postulates the existence of a radical after hydrogen abstraction from the arachidonic acid. N1,N3-diaryl-, N1-aryl-N3-alkyl-benzamidrazones and N1-arylacetamidrazones are strong inhibitors of the soja lipoxygenase.
