1313613-04-5Relevant articles and documents
Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1
Bachovchin, Daniel A.,Zuhl, Andrea M.,Speers, Anna E.,Wolfe, Monique R.,Weerapana, Eranthie,Brown, Steven J.,Rosen, Hugh,Cravatt, Benjamin F.
, p. 5229 - 5236 (2011/10/09)
The serine hydrolase protein phosphatase methylesterase-1 (PME-1) regulates the methylesterification state of protein phosphatase 2A (PP2A) and has been implicated in cancer and Alzheimer's disease. We recently reported a fluorescence polarization-activit