1313613-22-7

Upstream product

• 1117893-60-3 4-{4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one 
• 1313613-18-1 [4-(3-oxo-morpholin-4-yl)phenyl]carbamic acid benzyl ester 
• 29518-11-4 4-phenylmorpholin-3-one 
• 446292-04-2 4-(4-nitrophenyl)-3-morpholinone 
• 438056-69-0 4-(4-aminophenyl)morpholin-3-one 
• 122-98-5 2-Anilinoethanol 
• 107-45-9 tert-Octylamine 
• 1117893-61-4 R-(2-oxo-3-((4-(3-oxo-morpholinyl)phenyl)oxazolidin-5-yl))methylmethanesulfonate 

Downstream Products

• 366789-02-8 Rivaroxaban 
• 1313613-23-8 5-chloro-N-tert-octyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF RIVAROXABAN AND INTERMEDIATES THEREOF

A process for the preparation of rivaroxaban, or a pharmaceutically acceptable salt thereof, or a solvate thereof, including a hydrate, comprising submitting an amine compound of formula (III) wherein R1 is a (C4-C10)-alkyl radical which is attached to the N atom by a tertiary C atom, first to an acylation reaction and then to a dealkylation reaction.