1117893-60-3

Usage

Structure

Heterocyclic organic compound

Rings

Morpholine ring, oxazolidinone ring

Functional groups

Phenyl, hydroxymethyl

Potential uses

Chemical reactions, pharmaceutical applications

Therapeutic activities

Potentially therapeutic

Implications

Development of new drugs

Interest

Further research potential, application in various fields

Upstream product

• 124-38-9 carbon dioxide 
• 1447919-71-2 4-(4-((R)-5-((phenyloxycarbonyloxy)methyl)-2-oxo-oxazolidin-3-yl)phenyl)-morpholin-3-one 
• 1447919-69-8 acetic acid-1-benzyloxymethyl-2-{[(R)-(3-oxo-morpholin-4-yl)-phenyl]-chlorocarbonyl-amino} ethyl ester 
• 1447919-68-7 acetic acid-1-benzyloxymethyl-2-[(R)-4-(3-oxo-morpholin-4-yl)phenylamino]-ethylester 
• 1117893-58-9 4-(4-(R)-3-benzyloxy-2-hydroxy-propylamino)phenyl-morpholin-3-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1446022-14-5 butyric acid-2(R)-2-hydroxy-3-[4-(3-oxo-morpholin-4-yl)phenylamino]-propyl ester 
• 1447919-65-4 4-[4-{(R)-2,3-dihydroxy-propylamino}phenyl]morpholin-3-one 
• 1313613-18-1 [4-(3-oxo-morpholin-4-yl)phenyl]carbamic acid benzyl ester 
• 1447919-66-5 (S)-butyric acid-2-butyryloxy-1-(chloromethyl)-ethyl ester 
• 60827-45-4 (S)-3-chloropropan-1,2-diol 
• 1446022-15-6 butyric acid-2-oxo-5(R)-3-[4-(3-oxomorpholin-4-yl)-phenyl]oxazolidin-5-yl-methyl ester 
• 29518-11-4 4-phenylmorpholin-3-one 
• 446292-04-2 4-(4-nitrophenyl)-3-morpholinone 

Downstream Products

• 1117893-61-4 R-(2-oxo-3-((4-(3-oxo-morpholinyl)phenyl)oxazolidin-5-yl))methylmethanesulfonate 
• 366789-02-8 Rivaroxaban 
• 1313613-19-2 4-(4-((S)-5-(tert-butylaminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one 
• 1313613-22-7 4-(4-((S)-5-(tert-octylaminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one 
• 1313613-21-6 5-chloro-N-tert-butyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide 
• 1313613-23-8 5-chloro-N-tert-octyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide 
• 1313613-20-5 4-(4-((S)-5-(tert-butylaminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one methanesulfonic salt 
• 446292-08-6 2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione 
• 1446022-16-7 (S)-4-(4-(5-(aminomethyl)-2-oxo-oxazolidin-3-yl)phenyl)morpholin-3-one formate salt 
• 1446022-18-9 (S)-4-(4-(5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one L-(+)-mandelate 
• 1424942-80-2 (R)-(2-oxo-3-(4-(3-oxo-morpholino)phenyl)oxazolidin-5-yl)methyl 4-methylbenzene sulfonate 
• 1252018-26-0 4-[4-((R)-5-(iodomethyl)-2-oxo-oxazolidin-3-yl)phenyl]-morpholin-3-one 
• 1251952-73-4 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one p-toluenesulfonic acid salt 
• 1349248-79-8 4-{4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one 

Relevant academic research and scientific papers

Stereocontrolled, Divergent, Al(lll)-Catalyzed Coupling of Chiral N-Aryl Epoxy Amines and CO2

A divergent coupling reaction was achieved between N-aryl epoxy amines and CO2. By using two different cocatalysts, tetrabutylammonium iodide (TBAI) or 4-dimethylaminopyridine (DMAP) together with an Al(III) Lewis acid, cyclic carbonates or oxazolidinones were selectively produced through two distinct reaction pathways, respectively. The proposed reaction mechanism was supported by the stereochemical determination of the products. A gram-scale production of Linezolid was successfully achieved.

Synthetic method of rivaroxaban intermediate 5-hydroxy methyl oxazolidinone derivative

The invention provides a synthetic method of a rivaroxaban intermediate 5-hydroxy methyl oxazolidinone derivative, and concretely provides a method for preparing a rivaroxaban intermediate (I). The synthetic method comprises the following steps: 1) a comp

PROCESSES AND INTERMEDIATES FOR PREPARING RIVAROXABAN

The invention discloses processes for the preparation of rivaroxaban and its pharmaceutically acceptable salts, solvates, and hydrates thereof. The invention also relates to novel intermediates for the preparation of rivaroxaban.

PROCESSES FOR THE PREPARATION OF 5-CHLORO-N-({(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-1,3-OXAZOLIDIN-5-YL}METHYL)-2-THIOPHENE-CARBOXAMIDE AND INTERMEDIATES THEREOF

The present invention relates to processes for the preparation of oxazolidinone derivatives. More particularly the present invention provides processes for the preparation of 5-chloro-N-( {(5S)-2-oxo-3-[4-(3-oxo-4-moφholinyl)phenyl]-1,3-oxazolidin-5-yl methyl)-2-thiophene-carboxamide and intennediates thereof. Where L is a leaving group like halogen atom (F, CI, Br, I) or -OS02R where R = C'-4 alkyl straight chain or branched chain, sub or unsubstituted aryl, sub or unsub aryl alkyl; with a suitable reagent to provide the compound of formula (II). The reaction step is performed by reacting the compound of formula (IV) with amine source which may be dissolved in solvent like water or alcohol. For example ammonium hydroxide.

PROCESSES AND INTERMEDIATES FOR PREPARING RIVAROXABAN

The invention discloses processes for the preparation of rivaroxaban and its pharmaceutically acceptable salts, solvates, and hydrates thereof. The invention also relates to novel intermediates for the preparation of rivaroxaban.

PROCESS FOR THE PREPARATION OF RIVAROXABAN AND INTERMEDIATES THEREOF

A process for the preparation of rivaroxaban, or a pharmaceutically acceptable salt thereof, or a solvate thereof, including a hydrate, comprising submitting an amine compound of formula (III) wherein R1 is a (C4-C10)-alkyl radical which is attached to the N atom by a tertiary C atom, first to an acylation reaction and then to a dealkylation reaction.