1313712-88-7Relevant articles and documents
A synthetic approach toward a self-regulated insulin delivery system
Matsumoto, Akira,Ishii, Takehiko,Nishida, Junko,Matsumoto, Hiroko,Kataoka, Kazunori,Miyahara, Yuji
, p. 2124 - 2128 (2012)
Protein-free: A hydrogel containing phenylboronate was optimized so as to undergo rapid glucose-dependent changes in the state of hydration under physiological aqueous conditions. A localized dehydration of the gel surface to form a "skin layer" enabled control of the release of insulin from the gel. This dehydration is induced by fluctuations in the glucose concentration in the range between normo- and hyperglycemia. Copyright
Phenylboronic Acid Monomer and Phenylboronic Acid Polymer
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Page/Page column 4-5, (2012/11/13)
Disclosed are a phenylboronic acid monomer and a phenylboronic acid polymer, each of which can have a pKa value suitable for the use under physiological environments and can be used for various applications. The pheanylboronic acid monomer has a structure represented by formula (13) and therefore has high hydrophilicity, can have a satisfactorily low pKa value when the phenyl ring is fluorinated, and can have a polymerizable unsaturated bond. The phenylboronic acid monomer has high hydrophilicity at a pKa value of 7.4 or less which is a physiological level, and can be polymerized with a wide variety of monomers to produce polymers suitable for the intended purposes.