1313716-49-2Relevant academic research and scientific papers
The role of the 4″-hydroxyl on motilin agonist potency in the 9-dihydroerythromycin series
Liu, Yaoquan,Carreras, Christopher W.,Claypool, Mark,Myles, David C.,Shaw, Simon J.
, p. 3712 - 3714 (2011)
The role of the erythromycin 4″-hydroxyl group has been explored on the motilin agonist potential in the 9-dihydroerythromycin series of motilides. The compounds show potencies 2- to 4-fold superior to the corresponding hydroxylated compounds. The relationship is maintained when the 9-hydroxyl is alkylated to generate the corresponding 4″-deoxy-9-O-acetamido-9- dihydroerythromycins. However, concomitant with this increase in potency is an increase in hERG inhibition.
