38557-29-8

Usage

Uses

Used in Chemical Synthesis:
Iodocyclobutane is used as a reagent in chemical synthesis processes for its ability to participate in substitution reactions. The iodine atom in its structure can be replaced by other functional groups, enabling the creation of a wide range of chemical compounds.
Used in Pharmaceutical Industry:
Iodocyclobutane is used as an intermediate in the synthesis of pharmaceutical compounds. Its reactivity in substitution reactions allows for the development of new drug molecules with potential therapeutic applications.
Used in Organic Chemistry Research:
Iodocyclobutane serves as a model compound in organic chemistry research, providing insights into the behavior of halocycloalkanes and their reactions. It helps researchers understand the mechanisms and outcomes of various chemical reactions involving cycloalkanes with halogen atoms.
While specific applications of iodocyclobutane may vary depending on the industry and research focus, its potential uses in chemical synthesis, pharmaceuticals, and organic chemistry research highlight its importance in the field of chemistry.

Upstream product

• 4399-47-7 Bromocyclobutane 
• 33574-02-6 cyclopropylmethyl iodide 
• 157-33-5 bicyclo[1.1.0]butane 

Downstream Products

• 1280201-09-3 3-cyclobutyl-1-(2,6-dimethyl-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester 
• 1313716-49-2 C₄₀H₇₃NO₁₂ 

Relevant academic research and scientific papers

Vibrational Spectra and Conformations of (Iodomethyl)cyclopropane and Epiiodohydrin

The infrared (4000-400 cm-1) spectra of (iodomethyl)cyclopropane and epiiodohydrin in all three physical states have been recorded.The Raman (3500-50 cm-1) spectra of these two molecules in condensed phases have also been obtained.For (iodomethyl)cyclopropane no multiple Q branches were observed in the gase-phase infrared spectrum nor were any liquid-phase peaks observed to vanish upon crystallization.On the basis of these data and on the liquid-phase Raman depolarization ratios (which suggest that all observed Raman lines are polarized) it has been concluded that (iodomethyl)cyclopropane exists solely in the (nonsymmetric) gauche conformation in all states of matter.On the other hand, epiiodohydrin exhibits several gas-phase infrared band contours with "extra" Q branches and ten liquid-phase Raman conformer doublets, wherein one member of each doublet disappears when the annealed solid phase is obtained.These data have been interpreted in terms of a gauche-1 (70percent)/gauche-2 (30percent) conformational equilibrium for liquid epiiodohydrin at room temperature, with only the gauche-1 conformer remaining in the crystalline sample.From a variable-temperature (-74 to 25 deg C) study of the base-line-resolved liquid-phase Raman doublet at 940/914 cm-1, an enthalpy difference between conformers of 0.50 +/- 0.05 kcal/mol has been determined, with the gauche-1 conformer the more stable.No evidence for a cis conformation of either molecule was found, apparently as a result of strong steric interactions between the iodine atom and β-ring hydrogen atoms.For these molecules, vibrational assignments, which are in excellent agreement with the vibrational assignments of other (halomethyl)cyclopropanes and epihalohydrins, have also been proposed.