1313752-26-9

Upstream product

• 100-39-0 benzyl bromide 
• 183008-59-5 2-(tert-butyl)-2-methyl-1,3-dioxolan-4-one 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 20312-36-1 L-3-phenyllactic acid 

Relevant academic research and scientific papers

Diastereoselective radical mediated alkylation of a chiral glycolic acid derivative

Radical alkylation of 2-(tert-butyl)-2-methyldioxolan-4-one, a chiral equivalent of glycolic acid, occurs with good to high diastereoselectivity that compares favorably with the corresponding enolate alkylation. The importance of the position of the trans

Addition reaction of benzylbenzylidenenamine to lithium enolates of 1,3-dioxolan-4-one: Synthesis of 2-phenylisoserines

The synthesis of two new 2-phenylisoserines, each bearing a quaternary stereocenter is described. These compounds, which are analogs of the amino acid side chain found in taxol and taxotere, were obtained by addition of the lithium enolates of (2S,5S)-2-isopropyl-5-phenyl-1,3- dioxolan-4-one and (2S,5S)-2-tert-butyl-2-methyl-5-phenyl-1,3-dioxolan-4-one to benzylbenzylideneamine in the presence of BF3·O(Et) 2. The diastereomeric mixtures were separated in each case and the absolute configurations thereof were determined by X-ray analysis. ARKAT-USA, Inc.