13138-33-5

Usage

Uses

Used in Pharmaceutical Industry:
3-Aminopropylphosphonic acid is used as a selective antagonist for the GABA(C) receptor. This application is significant in the development of drugs targeting neurological disorders and conditions related to the GABAergic system.
Used in Nanotechnology and Electrochemistry:
In the field of nanotechnology and electrochemistry, 3-aminopropylphosphonic acid is utilized for modifying indium-tin oxide electrodes. The relative nonspecific binding of DNA-conjugated gold nanoparticles (AuNPs) to these modified electrodes is examined by measuring the electrocatalytic anodic current of hydrazine caused by the nonspecifically absorbed AuNPs. This application aids in the advancement of biosensors and other related technologies.

Biochem/physiol Actions

GABAB receptor agonist; antagonist of basal prolactin secretion.

InChI:InChI=1/C3H10NO3P/c4-2-1-3-8(5,6)7/h1-4H2,(H2,5,6,7)/p-1

Upstream product

• 50-00-0 formaldehyd 

Downstream Products

• 620969-29-1 {3-[5-(3,5-dichloro-phenylsulfanyl)-4-isopropyl-1-pyridin-4-ylmethyl-1H-imidazol-2-ylmethoxycarbonylamino]-propyl}-phosphonic acid 
• 1609063-40-2 (3-{[4-(1-{[5-(3,4-dimethylphenyl)-1,3,4-oxadiazol-2-yl]thio}ethyl)benzyl]amino}propyl)phosphonic acid 
• 1614222-55-7 [3-({3-bromo-4-[(5-phenylpentyl)thio]benzyl}amino)propyl]phosphonic acid 
• 1621522-71-1 [3-({3-methyl-4-[(5-phenyl-1-propyl-4,5-dihydro-1H-pyrazol-3-yl)methoxy]benzyl}amino)propyl]phosphonic acid 
• 96523-35-2 3-(benzyloxycarbonylamino)propyl phosphonic acid 
• 1622402-47-4 [3-({4-[5-(5-phenyl-1-propyl-4,5-dihydro-1H-pyrazol-3-yl)-1,2,4-oxadiazol-3-yl]benzyl}amino)propyl]phosphonic acid 
• 1622143-67-2 (3-{[4-(2-{[(2Z)-3,4-diphenyl-1,3-thiazol-2(3H)-ylidene]amino}ethyl)benzyl]amino}propyl)phosphonic acid 

Relevant academic research and scientific papers

Process for the manufacture of aminopolyalkylene-phosphonic acid compounds

A beneficial method for the manufacture of amino polyalkylene phosphonic acids, under substantial absence of hydrohalogenic acid, is disclosed. The method, in essence, is based on reacting narrowly defined ratios of phosphorous acid, an amine, a formaldehyde in presence of specific ranges of an acid catalyst having a pKa equal or inferior to 3.1. The inventive method is capable of yielding economically and quality operational/capacity advantages, in particular significantly reduced one-step cycle duration under exclusion of corrosion disadvantages and also is environmentally friendly without requiring, in that respect, anything more than nominal capital expenditures.

Process for the manufacture of aminoakylenephosphonic acid compounds in the presence of a heterogeneous catalyst

A beneficial method for the manufacture of amino polyalkylene phosphonic acids, under substantial absence of hydrohalogenic acid, is disclosed. The method, in essence, is based on reacting narrowly defined ratios of phosphorous acid, an amine and a formaldehyde in presence of a heterogeneous Broensted acid catalyst. The inventive method is capable of yielding economically and quality operational/capacity advantages, in particular significantly reduced one-step cycle duration under exclusion of corrosion disadvantages and also is environmentally friendly without requiring, in that respect, anything more than nominal capital expenditures.

Method and compositions for identifying anti-HIV therapeutic compounds

Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.

Method and compositions for identifying anti-HIV therapeutic compounds

Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.