96523-35-2

Upstream product

• 13138-33-5 3-aminopropanephosphonic acid 
• 501-53-1 benzyl chloroformate 
• 5041-33-8 N-(Benzyloxycarbonyl)allylamine 

Downstream Products

• 106235-16-9 1,2-di-O-hexadecanoyl-sn-glycerol 3-(3-benzyloxycarbonylaminopropyl)phosphonate 
• 106235-15-8 1,2-di-O-octadecyl-sn-glycerol 3-(3-benzyloxycarbonylaminopropyl)phosphonate 
• 1404216-66-5 benzyl N-(3-{bis[3-(octadecyloxy)propoxy]phosphoryl}propyl)carbamate 
• 1404216-43-8 {[(3-{[(benzyloxy)carbonyl]amino}propyl)({[(2,2-dimethylpropanoyl)oxy]methoxy})phosphoryl]oxy}methyl 2,2-dimethylpropanoate 

Relevant academic research and scientific papers

A novel approach to phosphonic acids from hypophosphorous acid

A novel access to phosphonic acids via Pd-catalyzed tandem carbon-phosphorus bond formation-oxidation processes was developed. The procedures involve atom-economical and environmentally friendly functionalization reactions of hypophosphorous acid (H3PO2) and H-phosphinic acids [RP(O)(OH)(H)].

Synthesis of Glycerophosphonolipids Containing Aminoalkylphosphonic Acids

1,2-Di-O-octadecyl- and 1,2-di-O-hexadecanoyl-sn-glycerol 3-(2-aminoethyl)phosphonate (21) and (22) and the (3-aminopropyl)phosphonate analogues (23) and (24) were prepared with the aim of obtaining enzyme (lipase)-stable liposomes.New reactions were devised and classic methodologies were modified in order to transform D-mannitol (6) into optically pure 1,2-di-O-substituted sn-glycerols (12) and (13) (R=C18H37 and C15H31CO).Benzyloxycarbonylaminoalkylphosphonic acids (5a) and (5b) were then coupled with the glycerols by means of condensing reagents such as 2,4,6-triisopropylbenzenesulphonyl chloride.The resulting N-protected lipids were catalitically hydrogenated to furnish compounds (21)-(24) in overall yields of 10-20 percent from compound (6).