131380-94-4Relevant academic research and scientific papers
Application of chiral bisoxazoline metal complex
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Paragraph 0021; 0039-0049, (2019/11/28)
The invention provides application of a chiral platinum complex (I). The chiral platinum complex (I) used as an anticancer reagent shows better inhibitory activity in A5499 (lung cancer), KB (nasopharyngeal cancer), KB-VIn (drug-resistant nasopharyngeal carcinoma), MDA-MB-231 (human breast cancer cells) and MCF-7 (breast cancer cells) tests, and the chemical formula of the chiral platinum complex(I) is shown in the description. The invention further provides application of a chiral zinc complex (II). The chiral zinc complex (II) used as an anticancer reagent shows better inhibitory activity in A549 (lung cancer), KB (nasopharyngeal cancer) and KB-VIn (drug-resistant nasopharyngeal carcinoma), human breast cancer cells MDA-MB-231 and breast cancer cells MCF-7 tests, and the chemical formula of the chiral zinc complex (II) is shown in the description.
Synthesis of Optically Active Bis(2-oxazolines): Crystal Structure of a 1,2-Bis(2-oxazolinyl)benzene * ZnCl2 Complex
Bolm, Carsten,Weickhardt, Konrad,Zehnder, Margareta,Ranff, Tobias
, p. 1173 - 1180 (2007/10/02)
Dinitriles (5-7, 12, 13) react with enantiomerically pure β-amino alcohols (8-11, 17) under zinc chloride catalysis to give optically active C2-symmetric bis(oxazolines). 1,2-Bis(2-oxazolin-2-yl)benzenes 1a-e are obtained under mild reaction conditions. 1H-NMR spectroscopy indicates the formation of 1:1 complexes 23 of these compounds with ZnCl2.The energy required for a conformational interconversion of zinc dichloride complex 23e was determined by variable-temperature 1H-NMR studies.An X-ray structure analysis was performed with the substituted zinc dichloride complex 23a.
