1313809-59-4

Upstream product

• 21865-50-9 6-bromo-1,2,3,4-tetrahydro-9H-carbazole 
• 824-94-2 p-methoxybenzyl chloride 
• 67-56-1 methanol 
• 1313809-70-9 6-bromo-9-(4-methoxybenzyl)-1,2,3,4-tetrahydro-9H-carbazole 

Relevant academic research and scientific papers

Sulfoxide-TFAA and nucleophile combination as new reagent for aliphatic C-H functionalization at indole 2α-position

Aliphatic C-H functionalization at indole 2α-position mediated by acyloxythionium species 1 generated from sulfoxide and acid anhydride has been developed. The combination of sulfoxide and TFAA with O-, N- and C-nucleophiles enabled introduction of various substituents in a one-pot procedure. Especially on utilizing DMSO, the combination provided a practical and efficient method for the synthesis of a wide range of 2α-substituted indoles. The Royal Society of Chemistry 2013.

Active thionium species mediated functionalization at the 2α-position of indole derivatives

A combination of dimethyl sulfoxide (DMSO) and trifluoroacetic anhydride (TFAA) mediates functionalization at the 2α-position of indole derivatives. Carbon and heteroatom nucleophiles were directly introduced via a one-pot procedure in excellent yields.