1313809-72-1Relevant academic research and scientific papers
Active thionium species mediated functionalization at the 2α-position of indole derivatives
Higuchi, Kazuhiro,Tayu, Masanori,Kawasaki, Tomomi
, p. 6728 - 6730 (2011)
A combination of dimethyl sulfoxide (DMSO) and trifluoroacetic anhydride (TFAA) mediates functionalization at the 2α-position of indole derivatives. Carbon and heteroatom nucleophiles were directly introduced via a one-pot procedure in excellent yields.
Sulfoxide-TFAA and nucleophile combination as new reagent for aliphatic C-H functionalization at indole 2α-position
Tayu, Masanori,Higuchi, Kazuhiro,Inaba, Masato,Kawasaki, Tomomi
supporting information, p. 496 - 502 (2013/02/23)
Aliphatic C-H functionalization at indole 2α-position mediated by acyloxythionium species 1 generated from sulfoxide and acid anhydride has been developed. The combination of sulfoxide and TFAA with O-, N- and C-nucleophiles enabled introduction of various substituents in a one-pot procedure. Especially on utilizing DMSO, the combination provided a practical and efficient method for the synthesis of a wide range of 2α-substituted indoles. The Royal Society of Chemistry 2013.
