1313822-00-2

Upstream product

• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 6630-33-7 ortho-bromobenzaldehyde 
• 34824-58-3 2-(2-bromophenyl)-1,3-dioxolan 
• 1777-55-5 (4-methoxyphenacylidene)triphenyl phosphorane 
• 59259-01-7 2-<2-(1,3-dioxolanyl)>benzaldehyde 

Downstream Products

• 1313822-13-7 2-hydroxy-2-(4-methoxyphenyl)-2H-naphthalen-1-one 
• 1258512-39-8 2'-(4-methoxybenzoyl)-1,2'-spirobi[indene]-1,3-dione 

Relevant academic research and scientific papers

Catalytic Enantioselective Synthesis of Axially Chiral Diarylmethylidene Indanones

We describe the first atropselective Suzuki-Miyaura cross-coupling of β-keto enol triflates to access axially chiral (Z)-diarylmethylidene indanones (DAIs). The chemical, physical, and biological properties of DAIs are unknown, despite their being structurally similar to arylidene indanones, primarily due to the lack of racemic or chiral methods. Through this work, we demonstrate a general and efficient protocol for the racemic as well as the atropselective synthesis of (Z)-DAIs. An unusual intramolecular Morita-Baylis-Hillman reaction is utilized for the Z-selective synthesis of β-keto enol triflates.

Nonenzymatic Dynamic Kinetic Resolution of in situ Generated Hemithioacetals: Access to 1,3-Disubstituted Phthalans

The first nonenzymatic DKR reaction of hemithioacetals is developed. Hemithioacetals were formed in situ via thiol addition and subsequently underwent an intramolecular oxa-Michael reaction. The scope of the reaction was quite broad ranging from aliphatic to aromatic substituents and 1,3-disubstituted-1,3-dihyroisobenzofuran products were obtained in good yields with moderate diastereoselectivities and high enantioselectivities. (Figure presented.).

N-Heterocyclic carbene catalyzed intramolecular crossed aldehyde-ketone benzoin condensation in the chalcone of o-phthalaldehyde: A facile synthesis of naphthalenones

The intramolecular crossed aldehyde-ketone benzoin condensation in the chalcone of o-phthalaldehyde (OPA) catalyzed by N-heterocyclic carbene (NHCs) generated in situ from readily available imidazolium and thiazolium salts is described. In this reaction,