131385-12-1

Basic information

• Product Name: (3R-cis)-1,3,4,5-tetrahydro-1-allyl-3-hydroxy-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one
• Synonyms: (3R-cis)-1,3,4,5-tetrahydro-1-allyl-3-hydroxy-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one
• CAS NO: 131385-12-1
• Molecular Weight: 391.39
• Mol File: 131385-12-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3R-cis)-1,3,4,5-tetrahydro-1-allyl-3-hydroxy-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3R-cis)-1,3,4,5-tetrahydro-1-allyl-3-hydroxy-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one(131385-12-1)
• EPA Substance Registry System: (3R-cis)-1,3,4,5-tetrahydro-1-allyl-3-hydroxy-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one(131385-12-1)

Safety Data

• Hazardous Substances Data: 131385-12-1(Hazardous Substances Data)

Upstream product

• 111605-09-5 (3S,4S-trans)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 138337-24-3 (3S,4S)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-hydroxy-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 111688-58-5 (3S,4S-trans)-3-carboxy-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one (S)-α-methylbenzylamine salt 
• 127061-43-2 (3R-cis)-3-(hydroxy)-1,3,4,5-tetrahydro-4-[4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one 
• 106-95-6 allyl bromide 

Downstream Products

• 138353-58-9 (3R,4S-cis)-1-(formylmethyl)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-acetoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 131385-00-7 (3R-cis)-1,3,4,5-tetrahydro-1-(formylmethyl)-3-hydroxy-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one 

Relevant articles and documents

Benzazepinone calcium channel blockers. 2. Structure-activity and drug metabolism studies leading to potent antihypertensive agents. Comparison with benzothiazepinones

As part of a program to discover potent antihypertensive analogues of diltiazem (3a), we prepared 1-benzazepin-2-ones (4). Benzazepinones competitively displace radiolabeled diltiazem, and show the same absolute stereochemical preferences at the calcium channel receptor protein. Derivatives of 4 containing a trifluoromethyl substituent in the fused aromatic ring show potent and long-acting antihypertensive activity. Studies of the metabolism of 4 lead to the metabolically stable antihypertensive calcium channel blockers 5a and 5c. Benzazepinone 5a is a longer acting and more potent antihypertensive agent than the second generation diltiazem analogue TA-3090 (3e).

Benzazepine derivatives

Novel compounds of the formula STR1 exhibit calcium channel blocking activity and are useful as cardiovascular agents.