138353-58-9

Basic information

• Product Name: (3R,4S-cis)-1-(formylmethyl)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-acetoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one
• CAS NO: 138353-58-9
• Molecular Weight: 435.4
• Mol File: 138353-58-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R,4S-cis)-1-(formylmethyl)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-acetoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4S-cis)-1-(formylmethyl)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-acetoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one(138353-58-9)
• EPA Substance Registry System: (3R,4S-cis)-1-(formylmethyl)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-acetoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one(138353-58-9)

Safety Data

• Hazardous Substances Data: 138353-58-9(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 131385-00-7 (3R-cis)-1,3,4,5-tetrahydro-1-(formylmethyl)-3-hydroxy-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one 
• 111605-09-5 (3S,4S-trans)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 138337-24-3 (3S,4S)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-hydroxy-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 127061-43-2 (3R-cis)-3-(hydroxy)-1,3,4,5-tetrahydro-4-[4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one 
• 111688-58-5 (3S,4S-trans)-3-carboxy-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one (S)-α-methylbenzylamine salt 
• 131385-12-1 (3R-cis)-1,3,4,5-tetrahydro-1-allyl-3-hydroxy-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one 

Relevant articles and documents

Benzazepinone calcium channel blockers. 2. Structure-activity and drug metabolism studies leading to potent antihypertensive agents. Comparison with benzothiazepinones

As part of a program to discover potent antihypertensive analogues of diltiazem (3a), we prepared 1-benzazepin-2-ones (4). Benzazepinones competitively displace radiolabeled diltiazem, and show the same absolute stereochemical preferences at the calcium channel receptor protein. Derivatives of 4 containing a trifluoromethyl substituent in the fused aromatic ring show potent and long-acting antihypertensive activity. Studies of the metabolism of 4 lead to the metabolically stable antihypertensive calcium channel blockers 5a and 5c. Benzazepinone 5a is a longer acting and more potent antihypertensive agent than the second generation diltiazem analogue TA-3090 (3e).