1313883-55-4

Usage

Structure

Heterocyclic compound with a five-membered ring

Explanation

A heterocyclic compound is a ring-shaped molecule containing atoms of different elements. In 1-(3-Bromo-phenyl)-azetidine, the five-membered ring includes one nitrogen atom, making it a heterocyclic compound.

Explanation

The azetidine ring is a four-membered nitrogen-containing ring, and the 3-bromo-phenyl substituent is attached to the nitrogen atom, giving the compound its unique structure.

Explanation

Due to its unique structure, 1-(3-Bromo-phenyl)-azetidine can be used as a starting material to create various molecular structures with potential applications in the pharmaceutical and agrochemical industries.

Explanation

The compound's properties and structure make it versatile for use in the development of new materials and as a reagent in various organic chemical reactions, contributing to the advancement of different industries.

Explanation

As an organic compound, 1-(3-Bromo-phenyl)-azetidine is generally soluble in organic solvents such as ethanol, methanol, and acetone, which allows for its use in various chemical reactions and processes.

Explanation

The compound is considered stable under normal conditions, meaning it does not readily decompose or react with other substances. This stability is important for its use in various applications and industries.

Explanation

As with many chemicals, 1-(3-Bromo-phenyl)-azetidine may pose health risks if not handled properly. It can be an irritant or toxic if ingested, inhaled, or comes into contact with the skin. Proper safety measures should be taken when working with 1-(3-Bromo-phenyl)-azetidine.

Functional Group

Azetidine ring with a 3-bromo-phenyl substituent

Application

Building block in the synthesis of pharmaceutical and agrochemical compounds

Use

Development of new materials and as a reagent in organic chemical reactions

Solubility

Soluble in organic solvents

Stability

Stable under normal conditions

Hazard

Potential irritant or toxic

Upstream product

• 503-29-7 azetidine 
• 591-18-4 1-Bromo-3-iodobenzene 
• 108-36-1 1,3-dibromobenzene 

Downstream Products

• 1313883-56-5 1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)azetidine 
• 1354491-08-9 (S)-ethyl 2-(1-(3-(azetidin-1-yl)phenyl)-3-methylnaphthalen-2-yl)-2-tert-butoxyacetate 
• 1354489-47-6 (S)-2-(1-(3-(azetidin-1-yl)phenyl)-3-methylnaphthalen-2-yl)-2-tert-butoxyacetic acid 

Relevant academic research and scientific papers

Descriptor ΔGC-O Enables the Quantitative Design of Spontaneously Blinking Rhodamines for Live-Cell Super-Resolution Imaging

Herein, we reported a simple, fast, and quantitative theoretical descriptor ΔGC-O that allows accurate predictions of a wide range of spontaneously blinking rhodamines. ΔGC-O denotes the Gibbs free energy differences between the closed and open forms of rhodamines and has a good linear relationship with experimental pKcycl values. This correlation affords an effective guide for the quantitative designs of spontaneously blinking rhodamines and eliminates trial-and-error. We have validated the predictive power of ΔGC-O via the development of two spontaneously blinking rhodamines of different colors and enhanced brightness. We also demonstrated their super-resolution imaging utilities in dynamic live-cell imaging. We expect that ΔGC-O will greatly facilitate the efficient creations of spontaneously blinking fluorophores and aid the advancements of super-resolution bioimaging techniques.

Self-flickering super-resolution fluorescent dye based on SNAP-tag technology as well as synthesis and application thereof

The invention provides self-flickering super-resolution fluorescent dye based on an SNAP-tag technology and synthesis and application thereof. The structure (1) of the fluorescent dye is shown in thespecification, intramolecular rotation of silicon rhodamine is inhibited by introducing azetidine, and therefore the fluorescent dye has the characteristics of high light stability, high quantum yieldand the like. Because of thermodynamic equilibrium of intramolecular spiralization of the dye, the fluorescent dye can flicker continuously and is further applied to super-resolution fluorescence imaging. In addition, the probe can be used for specifically labeling multiple target proteins fused with SNAP-tag labels in living cells, so that the tracing of the target proteins in the living cells is realized. The SNAP-tag self-flickering super-resolution fluorescent dye provided by the invention has wide application in the fields of protein labeling, protein-protein interaction, super-resolution fluorescence imaging and the like.

Self-flickering fluorescent dye for super-resolution fluorescence imaging and synthesis and application thereof

The invention provides a self-flickering fluorescent dye for super-resolution fluorescence imaging as well as synthesis and application thereof. According to the dye, azetidine is introduced into the4,5-sites of silicon rhodamine to inhibit intramolecular rotation, so that the characteristics of high quantum yield and high stability are achieved; meanwhile, under normal physiological conditions,fluorescence and non-fluorescence forms of the probe can be mutually converted through intramolecular interaction, so that the probe can be applied to living cell super-resolution imaging, the structural formula of the probe is shown as (1), and the dye can be combined with an antibody to perform specific labeling imaging on tubulin in cells. The dye can be widely applied to the fields of proteinlabeling, super-resolution fluorescence imaging and the like.

NOVEL TUNABLE PHOTOACTIVATABLE SILICON RHODAMINE FLUOROPHORES

The invention relates to a compound characterized by general formula (100), wherein R1 and R6 are H or F, R2, R3, R4 and R5 can be any substituent, R7, R8, RN1/s

PYRAZOLOPYRIMIDINE DERIVATIVES

The present invention covers Pyrazolopyrimidine compounds of general formula (I), in which n, o, X, Y, R, Q, R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds u

NAPHT- 2 -YLACETIC ACID DERIVATIVES TO TREAT AIDS

The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula (I).

NOVEL COMPOUNDS

The present invention relates to novel NADPH oxidase II inhibitors and their use in the treatment of diseases mediated by the NADPH oxidase enzymes.