131395-29-4

Upstream product

• 75-36-5 acetyl chloride 
• 175278-17-8 2-bromo-4-trifluoromethoxyaniline 
• 108-24-7 acetic anhydride 

Downstream Products

• 959855-43-7 2-methyl-1-(2-methylphenyl)-6-(trifluoromethoxy)-1H-benzimidazole 
• 1296885-58-9 N-[2-(3-methyl-but-2-enoyl)-4-trifluoromethoxy-phenyl]-acetamide 
• 1296885-52-3 N-[2-(3-hydroxy-3-methyl-but-1-ynyl)-4-trifluoromethoxy-phenyl]-acetamide 
• 1356388-74-3 2-(2-acetamido-5-trifluoromethoxyphenyl)pyridine 1-oxide 

Relevant academic research and scientific papers

Site-Specific Synthesis of Carbazole Derivatives through Aryl Homocoupling and Amination

We synthesized various carbazoles from anilines through a three-step process with good overall yields (up to 48percent). This process comprises N -acetylation, copper(0)-mediated Ullmann homocoupling, and acid-mediated intramolecular amination. It permits various functional groups on the substrate. Scale-up of the developed three-step synthetic route to carbazoles was also demonstrated.

2-Substituted-2,3-dihydro-1 H -quinolin-4-ones via acid-catalyzed tandem rupe rearrangement-donnelly-farrell ring closure of 2-(3′-hydroxypropynyl) anilines

A range of 2-substituted 2,3-dihydro-1H-quinolin-4-ones have been synthesized from anilines by a two-step process involving Sonogashira coupling with a propargyl alcohol then acid-catalyzed cyclization of the resulting 2-(3′-hydroxypropynyl)anilines. The cyclization reaction appears to proceed via regioselective rearrangement of the propargyl alcohol to an α,β-unsaturated ketone (Rupe rearrangement) and then 6-endo-trig ring closure (Donnelly-Farrell cyclization). The isolation of the α,β-unsaturated ketone intermediate in one example supports this pathway. Georg Thieme Verlag Stuttgart.

A palladium-catalyzed regiospecific synthesis of N-aryl benzimidazoles

(Chemical Equation Presented) Highly tolerated: A catalytic method employing [Pd2(dba)3] and XPhos or RuPhos permits the efficient synthesis of N-aryl benzimidazoles in regioisomerically pure form starting from ortho-halo-anilides (see scheme), and tolerates a wide range of functional groups, dba = trans,trans-dibenzylideneacetone.