1313990-75-8Relevant articles and documents
Kinetic resolution of α-Methylene- β- Hydroxy esters catalyzed by Acyl transfer catalyst An -PIQ
Jiang, Shan-Shan,Xu, Qin-Chang,Zhu, Ming-Yu,Yu, Xingxin,Deng, Wei-Ping
, p. 3159 - 3169 (2015)
A highly efficient nonenzymatic kinetic resolution of a series of structurally diverse racemic α-methylene-β-hydroxy esters utilizing the acyl transfer catalyst An-PIQ and propionic anhydride is reported. This procedure provides recovered alcohols with extremely high ee's (up to >99%) in reasonable conversions and excellent selectivity factors (S up to 108). Several synthetically important substrates were resolved in gram-scale reactions, and highly optically pure α-methylene-β-hydroxy esters were obtained with excellent S values and good yields.